Immunohistochemistry and Imaging Support Officer – Infrastructure and Facilities – 98084 – Grade 7

Fixed-term Full-time University of Birmingham in Education and Training , in Science
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  • Post Date : August 26, 2021
  • Apply Before : September 16, 2021
  • Salary: £30,942.00 - £40,322.00 / Per Annum
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Job Description

Position Details 

Infrastructure and Facilities – College of Medical and Dental Sciences

Location: University of Birmingham, Edgbaston, Birmingham UK

Full time starting salary is normally in the range £30,942 to £40,322, with potential progression once in post to £42,792

Grade 7

Full Time FTC up to 31 July 2023

Closing date 16 September 2021

Job Summary

The University has built critical mass and expertise in high-quality, complex multi-parameter histopathological and immunohistochemical imaging and analysis. Underpinning funding in the Arthritis Therapy Acceleration Programme, NIHR Birmingham Biomedical Research Centre and Cancer Research UK Birmingham Centre has supported development of academic and technical expertise in high resolution tissue imaging and analysis using cutting edge multiplex imaging equipment funded via the Wellcome Trust. This state-of-the-art equipment infrastructure is collectively termed the Molecular Histology Facility (MHF) and is located in the Institute of Translational Medicine (ITM).

The main role of the post holder will be the provision of an expert and specialist tissue image analysis service, providing of high quality, fully validated and automated immunohistochemistry, multiplex immunofluorescence, and in situ hybridisation services including Nanostring platforms alongside image analysis platforms including Visiopharm to enable immune-phenotyping and monitoring of primarily patient samples. This includes advising on experimental design and methodology, delivery of optimisation, validation and analysis services, and results interpretation. The post will contribute significantly to the identification and clinical validation of predictive biomarkers, facilitating the transition of academic and commercially-funded pre-clinical studies into clinical trials. Additionally, the post will help to establish a range of GCP-compliant diagnostic/prognostic and immune-monitoring assays which will be applied to clinical trials.

This will be under the academic guidance of Dr Andrew Filer and Professor Ben Willcox and supervised by the CRUK Birmingham Centre Digital Pathology Analyst. The post-holder will report to the Unit academic leads, and is expected to interact closely with other staff working within the MHF Infrastructure Hub, and also in the Human Biomaterials Resource Centre (HBRC), with local researchers, pathology staff and clinicians. Particularly close links will be maintained with the Department of Cellular Pathology at the neighbouring University Hospital Birmingham NHS Foundation Trust. Significant time may be spent working alongside local Pathologists to optimise and validate digital pathology analysis methods, and with industry supporting digital scoring for collaborative research projects.

The post-holder must be able to co-ordinate the delivery of these services according to the agreed specifications, time, and budgets, and in a manner compliant with the appropriate regulatory and quality standards. A sound knowledge of the regulations, legislation and governance arrangements applicable to clinical research, experience of handling human tissues, and good interpersonal, communication and negotiation skills are essential.

Main Duties

The post holder must ensure that all duties are performed in accordance with applicable ethical, regulatory and quality standards.

  • To manage and oversee the provision of the tissue image analysis service according to agreed timelines and budgets, and in a manner compliant with GCP and HTA regulations and quality standards.
  • To further the development of, and to provide a fully validated and automated immunochemistry service (single and multiplex antibody staining, in-situ hybridisation) in cancer and inflammation settings, and any other settings as appropriate.
  • To liaise with local researchers and external collaborators (academic and commercial) to provide specialist advice and support for the development of protocols and to aid data analysis. This will include the presentation of data (e.g. at local research meetings/seminars) and supporting research publications. The post-holder will therefore be expected to have sufficient knowledge and experience to be able to anticipate and understand needs, and to provide expert advice and guidance. He/she is likely to be involved with multiple projects.
  • To lead the training and development local researchers, clinicians and pathologists on all aspects of the tissue-based processing and IHC analytical services being delivered.
  • Be proactive in further developing ways to improve and develop the service and new techniques, and to improve the quality of analytical data produced.
  • To be responsible for ensuring that all equipment used to provide the tissue-based processing and analytical services are monitored and maintained in a manner which is compliant with HTA and MHRA regulations.
  • To keep up to date with current legal and regulatory requirements, and accepted quality standards e.g. Human Tissue Act 2004, laboratory GCP.
  • To contribute to the continued development and maintenance of the HBRC Quality Management System (QMS) to ensure compliance with quality standards and regulations, including writing/review of Standard Operating Procedures (SOPs) covering processing and analytical protocols, equipment use and maintenance, data handling and reporting.
  • To assist with internal and external audit procedures, and with regulatory inspections.
  • To help ensure safe laboratory practices are maintained.
  • Other duties commensurate with the grade and skill base of the post holder as directed by the Line Manager.

Knowledge, Skills, Qualifications and Experience Required

  • BSc (or equivalent), in a life or biological science, or biomedical science.
  • In-depth, up to date specialist knowledge and expertise in core techniques such as tissue processing, immunohistochemistry, in situ hybridisation, and ideally digital image analysis.
  • Knowledge of the legal and regulatory framework which governs the collection, storage, use and disposal of human tissue for clinical research, and laboratory GCP.
  • Ability to apply specialist knowledge and to identify problems (both simple and complex) and recommend solutions.
  • Ability to understand and anticipate the customer requirements, to develop and adapt the service to ensure solutions are developed and implemented.
  • Ability to work on own initiative and to prioritise needs to ensure continuity of service.
  • Competent computer-related, writing and presentation skills.
  • Effective communication, negotiation, time management and interpersonal skills.
  • A critical and intelligent attention to detail and high standards of accuracy.
  • Experience in managing multiple projects simultaneously, or managing a service facility.

 

Further particulars can be found here:http://www.download.bham.ac.uk/vacancies/jd/MDSFPs.pdf

Valuing excellence, sustaining investment 

We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working. 

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